[A new approach to the determining immunoglobulin free light chains in serum by TIA nephelometry].

@article{Wakasugi1996ANA,
  title={[A new approach to the determining immunoglobulin free light chains in serum by TIA nephelometry].},
  author={Keiichiro Wakasugi and Hiroyosi Suzuki and Misako Suzuki},
  journal={Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology},
  year={1996},
  volume={19 1},
  pages={87-93}
}
Immunoglobulin light chains exist in two distinct forms, as linked to heavy chains by disulfide bonds, and as free light chains (FLc). Neoplastic B-cell disorders are responsible for the major absolute elevations of FLc, which are almost all monoclonal. Free light chains are nephrotoxic, and patients with renal failure have elevated blood concentrations of FLc. Light chains of immunoglobulins have attracted clinical attention as one of the proteins constituting the amyloid fibrils. Moreover… CONTINUE READING