[A molecular basis for multidrug resistance and reversal of the resistance].

Abstract

Multidrug-resistance is frequently characterized by enhanced drug efflux resulting from a membrane glycoprotein of 170,000 daltons (P-glycoprotein). Analysis of cloned cDNAs for the human MDR 1 gene, whose product is the P-glycoprotein, indicates that P-glycoprotein is an energy-dependent drug-efflux system for cytotoxic hydrophobic anticancer drugs. We… (More)

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Cite this paper

@article{Akiyama1989AMB, title={[A molecular basis for multidrug resistance and reversal of the resistance].}, author={Shin'ichi Akiyama and A Yoshimura and H. Kikuchi and M Kamiwatari and Yuko Nagata and Kazuko Seto and Ranko Sakota and A H T Utsunomiya and Sachiyo Hanada and S. Hashimoto}, journal={Gan to kagaku ryoho. Cancer & chemotherapy}, year={1989}, volume={16 4 Pt 2-1}, pages={1266-72} }