[A coupled enzyme system for detection of phospholipase A2 inhibitors].

Abstract

A coupled assay of phospholipase-A2 and lipoxygenase that especially can be applied to the determination of phospholipase-A2-inhibition is described. A partialsynthetic dilinolenoylglycerophosphocholine is used as substrate in the form of mixed micelles with Twenn-20. Pentadienoic fatty acids primarily produced by venom phospholipase-A2 are peroxydized in a… (More)

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