[A comparative study of the development of drug differentiation between mexidol and phenazepam].

@article{Kalinina2005ACS,
  title={[A comparative study of the development of drug differentiation between mexidol and phenazepam].},
  author={Tatyana S. Kalinina and Tatiana A Voronina and E V Petrianina},
  journal={Eksperimental'naia i klinicheskaia farmakologiia},
  year={2005},
  volume={68 5},
  pages={7-10}
}
Interceptive stimulus properties of mexidol (50 and 100 mg/kg, i.p.) and phenazepam (2 mg/kg, i.p.) were compared using the standard operant model of liquid-reinforced drug discrimination (DD) procedure in male albino rats. Successful DD development has been shown in 100% of phenazepam-pretreated rats, while only 10% of mexidol-treated animals demonstrated DD. In the case of a high stimulus control, both mexidol and phenazepam DD manifestations showed high reproducibility (not less than 80… CONTINUE READING