[A case of pseudo-vaginal, perineoscrotal hypospadia with 5-alpha reductase deficiency].

@article{Wieacker1992ACO,
  title={[A case of pseudo-vaginal, perineoscrotal hypospadia with 5-alpha reductase deficiency].},
  author={Peter Wieacker and Ursula Flecken and Meinert Breckwoldt},
  journal={Geburtshilfe und Frauenheilkunde},
  year={1992},
  volume={52 2},
  pages={126-8}
}
A case of pseudovaginal perineoscrotal hypospadia (PPSH) is presented. This autosomal recessive disorder, also termed incomplete male pseudohermaphroditism type 2, is mostly caused by a deficiency of 5 alpha-reductase, which controls the conversion of testosterone to 5 alpha-dihydrotestosterone. In genital skin fibroblasts, the activity of the 5 alpha… CONTINUE READING