[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper.

@article{Brancaccio20174Fe4SCA,
  title={[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper.},
  author={Diego Brancaccio and Angelo Gallo and Mario Piccioli and Ettore Novellino and Simone Ciofi-Baffoni and Lucia Banci},
  journal={Journal of the American Chemical Society},
  year={2017},
  volume={139 2},
  pages={
          719-730
        }
}
The cellular toxicity of copper is usually associated with its ability to generate reactive oxygen species. However, recent studies in bacterial organisms showed that copper toxicity is also strictly connected to iron-sulfur cluster proteins and to their assembly processes. Mitochondria of eukaryotic cells contain a labile copper(I) pool localized in the matrix where also the mitochondrial iron-sulfur (Fe/S) cluster assembly machinery resides to mature mitochondrial Fe/S cluster-containing… CONTINUE READING
1
Twitter Mention

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

References

Publications referenced by this paper.