[4 + 2]-Annulations of aminocyclobutanes.


The first [4 + 2]-annulation between aminocyclobutanes and aldehydes to access tetrahydropyranyl amines is reported. With phthalimido cyclobutane dicarboxylates and aromatic aldehydes, tetrahydropyrans were obtained in 53-92% yield and 3:1-17:1 dr using scandium triflate or iron trichloride as catalyst. The use of thymine- or fluorouracil-substituted… (More)
DOI: 10.1021/acs.orglett.5b00149

3 Figures and Tables


  • Presentations referencing similar topics