[3H]spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy.

@article{Bokobza19843HspiperoneBD,
  title={[3H]spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy.},
  author={Bernard Bokobza and Merle Ruberg and Bernard Scatton and France Javoy-Agid and Yves Agid},
  journal={European journal of pharmacology},
  year={1984},
  volume={99 2-3},
  pages={167-75}
}
The density of D2-type dopamine receptors, measured by the binding of [3H]spiperone was normal in the substantia nigra, caudate nucleus and nucleus accumbens of Parkinsonian subjects and above control levels in the putamen, in spite of massive lesions of the dopaminergic neurons. Dopamine levels were reduced in the putamen, caudate nucleus, and nucleus accumbens by 97, 85 and 68%, respectively and by 78 and 93% in the pars compacta and pars reticulata of the substantia nigra. HVA levels were… CONTINUE READING
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