[3H]gabapentin may label a system-L-like neutral amino acid carrier in brain.

@article{Thurlow19933HgabapentinML,
  title={[3H]gabapentin may label a system-L-like neutral amino acid carrier in brain.},
  author={R J Thurlow and Jeffrey P. Brown and N S Gee and David R Hill and George Woodruff},
  journal={European journal of pharmacology},
  year={1993},
  volume={247 3},
  pages={341-5}
}
The ability of large neutral amino acids to interact with a site in mouse and pig brain labelled by [3H]gabapentin was examined. As previously described for rat tissue, [3H]gabapentin bound to synaptic plasma membranes prepared from mouse or pig cerebral cortex with high affinity (Kinetically derived KD = 14 and 17 nM for mouse and pig, respectively). Equilibrium binding in each species was inhibited by gabapentin and a range of large neutral amino acids. L-leucine (IC50 = 80 nM), L-isoleucine… CONTINUE READING

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