[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.

@article{Young19863HdynorphinAB,
  title={[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.},
  author={Elizabeth Anne Young and Jennifer M. Walker and Michael E. Lewis and Richard A. Houghten and J. H. Woods and Huda Akil},
  journal={European journal of pharmacology},
  year={1986},
  volume={121 3},
  pages={355-65}
}
We have previously demonstrated that [3H]dynorphin A selectively labels kappa opioid receptors in guinea-pig whole brain. In these current studies, using protection from inactivation by beta-chloronaltrexamine (beta-CNA), we are able to demonstrate that although dynorphin A prefers kappa receptors, it will label mu receptors when kappa receptors are not available, or present in only a small number. Thus, differences in numbers of mu and kappa receptors present in brain preparations are critical… CONTINUE READING