[3H]doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates.

@article{Tran19813HdoxepinIW,
  title={[3H]doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates.},
  author={V. Tran and R. Lebovitz and L. Toll and S. Snyder},
  journal={European journal of pharmacology},
  year={1981},
  volume={70 4},
  pages={
          501-9
        }
}
  • V. Tran, R. Lebovitz, +1 author S. Snyder
  • Published 1981
  • Chemistry, Medicine
  • European journal of pharmacology
  • [3H]Doxepin, a tricyclic antidepressant, binds to brain homogenates with two saturable components. The high affinity component, with a dissociation constant (KD) of 0.26 nM, is associated with histamine H1-receptors. This high affinity binding shows stereospecificity in that d-chlorpheniramine is 100 times more potent than the pharmacologically less active l-isomer. Its drug specificity and regional variation closely parallel those exhibited by [3H]mepyramine binding. The drug specificity of… CONTINUE READING
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