[3H]batrachotoxinin-A 20-alpha-benzoate binding to sodium channels in rat brain: sensitivity to tetrodotoxin and divalent cations.

@article{Garritsen19883HbatrachotoxininA2B,
  title={[3H]batrachotoxinin-A 20-alpha-benzoate binding to sodium channels in rat brain: sensitivity to tetrodotoxin and divalent cations.},
  author={A Garritsen and Adriaan P. IJzerman and Willem Soudijn},
  journal={European journal of pharmacology},
  year={1988},
  volume={145 3},
  pages={261-6}
}
The sodium channel blocker tetrodotoxin partially inhibited [3H]batrachotoxinin-A 20-alpha-benzoate binding to rat brain synaptosomes. This inhibition results from a decrease in the apparent affinity of the radioligand, which indicates that sites 1 and 2 of the sodium channel are not independent as thought previously. Computer-assisted data analysis allowed… CONTINUE READING