[3H]acetylcholine release from rat amacrine-like neurons is inhibited by adenosine A1 receptor activation.

@article{Santos19983HacetylcholineRF,
  title={[3H]acetylcholine release from rat amacrine-like neurons is inhibited by adenosine A1 receptor activation.},
  author={Paulo J. Santos and O L Caramelo and Ars{\'e}lio Pato Carvalho and Carlos B Duarte},
  journal={Neuroreport},
  year={1998},
  volume={9 16},
  pages={3693-8}
}
We studied the effect of endogenous adenosine on the release of [3H]acetylcholine ([3H]ACh) in cultures enriched (96.4+/-0.4%) in rat cholinergic amacrine-like neurons, as determined by labeling with an antibody against choline acetyltransferase. A small population of these cells also contained GABA. Using these cultures we observed that both [3H]ACh release, which was largely Ca2+-dependent, and 45Ca2+ influx, evoked by depolarization with 50 mM KCl, were increased when adenosine A1 receptor… CONTINUE READING