[3H]PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex.

@article{Myers19913HPK1A,
  title={[3H]PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex.},
  author={Ralph Myers and L G Manjil and R. S. J. Frackowiak and Jill E. Cremer},
  journal={Neuroscience letters},
  year={1991},
  volume={133 1},
  pages={20-4}
}
The peripheral-type benzodiazepine binding site (PTBBS) ligand, PK 11195, is known to be a marker of damage in the central nervous system, the binding being predominantly to macrophages. Using photochemically induced focal cortical ischaemia as a lesion model in the rat, we have investigated the detection of secondary lesions using [3H]PK 11195 and ex vivo autoradiography. Secondary lesions in the thalamus became apparent during the second week post-lesioning, at a time when [3H]PK 11195… CONTINUE READING