[3H]N6-(L-Phenylisopropyl) adenosine binding in brains from young and old rats

  title={[3H]N6-(L-Phenylisopropyl) adenosine binding in brains from young and old rats},
  author={R. M. Virus and T. Baglajewski and M. Radulova{\vc}ki},
  journal={Neurobiology of Aging},
  • R. M. Virus, T. Baglajewski, M. Radulovački
  • Published 1984
  • Chemistry, Medicine
  • Neurobiology of Aging
  • The binding of [3H]N6-(L-Phenylisopropyl) adenosine (L-PIA) to membrane preparations of whole brains from normal male Sprague-Dawley rats 12 and 84 weeks of age, respectively, was examined. Two populations of binding sites, probably corresponding to A1 and A2 adenosine receptors, were detected in both young and old rats. No statistically significant differences between young and old rats were detected but both the numbers of binding sites (Bmax) and dissociation constants (KD) for both high and… CONTINUE READING
    15 Citations

    Topics from this paper

    Pharmacology of the Adenosine System
    • 7
    Ageing‐related decline in adenosine A1 receptor binding in the rat brain: An autoradiographic study
    • 42
    • Highly Influenced


    Adenosine analogs and sleep in rats.
    • 237
    Sleep in young and old rats.
    • 90
    Protein measurement with the Folin phenol reagent.
    • 274,876
    Aging and sleep in the albino rat.
    • 51
    Statistical Methods
    • 33,807
    The role of adenosine and its nucleotides in central synaptic transmission
    • 759