[3H]Histamine uptake and release by astrocytes from rat brain: Effects of sodium deprivation, high potassium, and potassium channel blockers

Abstract

Histamine transport has been characterized in cultured astroglial cells of rat brain. The kinetics of [3H]-histamine uptake yielded a Km of 0.19±0.03 μM and a Vmax of 3.12±0.75 pmol×mg protein−1×min−1. Transport system revealed high affinity for histamine and an approximately ten times higher capacity than that shown in cultured glial cells of chick… (More)
DOI: 10.1007/BF01006814

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