[3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain.

@article{Griffante20063HGR205171DS,
  title={[3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain.},
  author={Cristiana Griffante and Renzo Carletti and Filippo Andreetta and Mauro A Corsi},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 1},
  pages={39-45}
}
1 In this study, [(3)H]GR205171 (3(S)-(2-methoxy-5-(5-trifluoromethyltetrazol-1-yl)-phenylmethylamino)-2(S)-phenylpiperidine), a potent and selective NK1 receptor antagonist, was characterised in autoradiographic studies in gerbil brain and in binding experiments on homogenates from gerbil and human brain cortex and striatum. 2 In autoradiographic studies in gerbil brain, highest levels of [(3)H]GR205171 binding sites were observed in caudate putamen, nucleus accumbens, medial and cortical… CONTINUE READING

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