[3H]Etorphine binding activity in early chick embryos: brain and body tissue.

@article{Gibson19823HEtorphineBA,
  title={[3H]Etorphine binding activity in early chick embryos: brain and body tissue.},
  author={David A. Gibson and Antonia Vernadakis},
  journal={Brain research},
  year={1982},
  volume={256 1},
  pages={23-9}
}
Stereospecific [3H]etorphine binding has been detected in chick embryos as early as day 4 of incubation in both brain and body tissue. By day 10 of incubation [3H]etorphine stereospecific binding activity is not detectable in nonneuronal tissue. The ubiquitous opiate binding sites early in embryogenesis are high affinity and respond to ion and GTP regulation in a manner similar to adult brain tissue. We interpret our observations to indicate all embryonic cells prior to cell differentiation… CONTINUE READING