[35S]t-butylbicyclophosphorothionate binding sites in susceptible and cyclodiene-resistant houseflies

  title={[35S]t-butylbicyclophosphorothionate binding sites in susceptible and cyclodiene-resistant houseflies},
  author={N Mariano Anthony and Eric A. Benner and James J. Rauh and David B Sattelle},
  journal={Neurochemistry International},
4-aminobutyric acid (GABA)-gated chloride ion channels are important molecular targets for a number of polychlorocycloalkane compounds including cyclodiene insecticides. Previous radioligand binding studies have indicated that cyclodiene insecticides are potent inhibitors of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to housefly thorax and abdomen membranes. In the present study, a laboratory-reared, cyclodiene-resistant (CYW) housefly strain (Musca domestica) showed resistance to… CONTINUE READING

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