[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain.

  title={[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain.},
  author={J. W. Pan and Robin A de Graaf and Kitt Falk Petersen and Gerald I Shulman and Hoby P. Hetherington and Douglas L. Rothman},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={22 7},
Infusions of [2,4-13C2]-beta-hydroxybutyrate and 1H-13C polarization transfer spectroscopy were used in normal human subjects to detect the entry and metabolism of beta-hydroxybutyrate in the brain. During the 2-hour infusion study, 13C label was detectable in the beta-hydroxybutyrate resonance positions and in the amino acid pools of glutamate, glutamine, and aspartate. With a plasma concentration of 2.25 +/- 0.24 mmol/L (four volunteers), the apparent tissue beta-hydroxybutyrate concentration… CONTINUE READING