[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1.

@article{Balzarini199225BisOtertbutyldimethylsilyl3spi,
  title={[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1.},
  author={Jan Marie Rene Balzarini and Mar{\'i}a-Jes{\'u}s P{\'e}rez-P{\'e}rez and Ana San-F{\'e}lix and Sonsoles Vel{\'a}zquez and Mar{\'i}a Jos{\'e} Camarasa and Erik De Clercq},
  journal={Antimicrobial agents and chemotherapy},
  year={1992},
  volume={36 5},
  pages={
          1073-80
        }
}
The [2',5'-bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino- 1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of ribofuranosylthymine, uridine, 5-bromouridine, 5-methylcytidine, inosine, and adenosine are potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) but not of other retroviruses (HIV-2, simian immunodeficiency virus, or Moloney murine sarcoma virus). The 50% effective concentration (EC50) of the most active TSAO congeners for inhibition of HIV-1… CONTINUE READING
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