[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.

@article{Burns200718FMK9470AP,
  title={[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.},
  author={H. Donald Burns and Koen Van Laere and Sandra M. Sanabria-Boh{\'o}rquez and Terence G. Hamill and Guy Bormans and Wai-si Eng and Ray G. Gibson and Christine Ryan and Brett Connolly and Shil Patel and Stephen Krause and Amy Vanko and Anne van Hecken and Patrick Dupont and Inge de Lepeleire and P. M. Rothenberg and S Aubrey Stoch and J{\'e}r{\^o}me C{\^o}t{\'e} and William K. Hagmann and James P. Jewell and Linus S. Lin and Ping Liu and Mark T. Goulet and Keith Gottesdiener and John Arthur Wagner and Jan N.J.M. de Hoon and Luc Mortelmans and Tung Ming Fong and Richard J. Hargreaves},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 23},
  pages={
          9800-5
        }
}
[(18)F]MK-9470 is a selective, high-affinity, inverse agonist (human IC(50), 0.7 nM) for the cannabinoid CB1 receptor (CB1R) that has been developed for use in human brain imaging. Autoradiographic studies in rhesus monkey brain showed that [(18)F]MK-9470 binding is aligned with the reported distribution of CB1 receptors with high specific binding in the cerebral cortex, cerebellum, caudate/putamen, globus pallidus, substantia nigra, and hippocampus. Positron emission tomography (PET) imaging… CONTINUE READING

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