[18F]Fluoro-Hydroxyphenethylguanidines: Efficient Synthesis and Comparison of Two Structural Isomers as Radiotracers of Cardiac Sympathetic Innervation.

@article{Jung201718FFluoroHydroxyphenethylguanidinesES,
  title={[18F]Fluoro-Hydroxyphenethylguanidines: Efficient Synthesis and Comparison of Two Structural Isomers as Radiotracers of Cardiac Sympathetic Innervation.},
  author={Yong-Woon Jung and Keun Sam Jang and Guie Gu and Robert A. Koeppe and Phillip S. Sherman and Carole Quesada and David M Raffel},
  journal={ACS chemical neuroscience},
  year={2017},
  volume={8 7},
  pages={
          1530-1542
        }
}
Fluorine-18 labeled phenethylguanidines are currently under development in our laboratory as radiotracers for quantifying regional cardiac sympathetic nerve density using PET imaging techniques. In this study, we report an efficient synthesis of 18F-hydroxyphenethylguanidines consisting of nucleophilic aromatic [18F]fluorination of a protected diaryliodonium salt precursor followed by a single deprotection step to afford the desired radiolabeled compound. This approach has been shown to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

Similar Papers

Loading similar papers…