[18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model

@article{Dubois200818FEF3IN,
  title={[18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model},
  author={Ludwig Dubois and Willy Landuyt and Lieselotte Cloetens and Anne Bol and Guy Bormans and Karin Haustermans and Daniel Labar and Johan Nuyts and Vincent Gr{\'e}goire and Luc Mortelmans},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2008},
  volume={36},
  pages={209-218}
}
The aim of this investigation was to quantitatively compare the novel positron emission tomography (PET) hypoxia marker 2-(2-nitroimidazol-1-yl)-N-(3[18F],3,3-trifluoropropyl)acetamide ([18F]EF3) with the reference hypoxia tracer [18F]fluoromisonidazole ([18F]FMISO). [18F]EF3 or [18F]FMISO was injected every 2 days into two separate groups of rats bearing syngeneic rhabdomyosarcoma tumours. In vivo PET analysis was done by drawing regions of interest on the images of selected tissues. The… CONTINUE READING
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