[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia

@inproceedings{BevanJones201818FAV1451BI,
  title={[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia},
  author={W R Bevan-Jones and Thomas Edmund Cope and P. Simon Jones and Luca Passamonti and Young T. Hong and Tim D. Fryer and Robert J Arnold and Kieren S. J. Allinson and Jonathan P Coles and Franklin I. Aigbirhio and Karalyn E. Patterson and John T. O'Brien and James B. Rowe},
  booktitle={Journal of neurology, neurosurgery, and psychiatry},
  year={2018}
}
INTRODUCTION Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology. It provides a useful model in which to test the specificity of in vivo binding of the putative tau ligand [18F]AV-1451, which is elevated in frontotemporal lobar degeneration tauopathies. METHODS AND RESULTS Seven patients (five with svPPA and two with 'right' semantic dementia) and 12 healthy controls… CONTINUE READING

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