[18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior

@article{Cannella201718FFluorodeoxyglucosePositronET,
  title={[18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior},
  author={Nazzareno Cannella and Alejandro Cosa-Linan and Mareike Roscher and Tatiane Teru Takahashi and Nils Vogler and Bj{\"o}rn W{\"a}ngler and Rainer Spanagel},
  journal={Frontiers in Psychiatry},
  year={2017},
  volume={8}
}
The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life… 
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