[131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity

@article{Zanzonico2005131IFIAULO,
  title={[131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity},
  author={Pat Zanzonico and Guenther Koehne and Humilidad F. Gallardo and Mikhail M. Doubrovin and Ekaterina S. Doubrovina and Ronald L Finn and Ronald G. Blasberg and Isabelle Rivi{\'e}re and Richard J. O’Reilly and Michel Sadelain and Steven M. Larson},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2005},
  volume={33},
  pages={988-997}
}
Donor T cells have been shown to be reactive against and effective in adoptive immunotherapy of Epstein-Barr virus (EBV) lymphomas which develop in some leukemia patients post marrow transplantation. These T cells may be genetically modified by incorporation of a replication-incompetent viral vector (NIT) encoding both an inactive mutant nerve growth factor receptor (LNGFR), as an immunoselectable surface marker, and a herpes simplex virus thymidine kinase (HSV-TK), rendering the cells… CONTINUE READING