[125I]Tyr10-cortistatin14 labels all five somatostatin receptors

  title={[125I]Tyr10-cortistatin14 labels all five somatostatin receptors},
  author={Sandra Siehler and Klaus Seuwen and Daniel Hoyer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The recently cloned rat preprocortistatin, which shows homology to the preprosomatostatin peptide, is thought to be enzymatically cleaved to cortistatin14 (CST14) similarly to somatostatin14 (SRIF14). High structural similarity of cortistatin14 compared to SRIF14 suggested binding properties to somatostatin receptors similar to SRIF14. In the present study, we expressed stably the five human somatostatin receptor subtypes (hsst1–hsst5) in CCL39 cells (Chinese hamster lung fibroblast cells). The… CONTINUE READING
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