[123I]Iomazenil spect imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain

@article{Sybirska1993123IIomazenilSI,
  title={[123I]Iomazenil spect imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain},
  author={E. Sybirska and J. Seibyl and J. Bremner and R. Baldwin and M. Al-Tikriti and C. Bradberry and R. Malison and Y. Zea‐Ponce and S. Zoghbi and M. During and A. Goddard and S. W. Woods and P. Hoffer and D. Charney and R. Innis},
  journal={Neuropharmacology},
  year={1993},
  volume={32},
  pages={671-680}
}
SPECT imaging with [123I]iomazenil was used to measure benzodiazepine (BZ) neuroreceptor occupancy of the agonist lorazepam administered at therapeutically relevant doses in humans and supratherapeutic doses in monkeys. Lorazepam at therapeutic doses (0.03 mg/kg, i.v.) administered 90 min after the bolus injection of [123I]iomazenil had no statistically significant effect (P > 0.12) on the washout rates of regional brain activities compared to that in control subjects, although human subjects… Expand
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