[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.

@article{Gerhard200311CRPK11195PI,
  title={[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.},
  author={Alexander Gerhard and Richard B. Banati and Gerhard Goerres and Annachiara Cagnin and Ralph Myers and Roger N. Gunn and Federico E. Turkheimer and Catriona D. Good and Christopher J. Mathias and Niall Quinn and Johannes Schwarz and David J. Brooks},
  journal={Neurology},
  year={2003},
  volume={61 5},
  pages={686-9}
}
Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195… CONTINUE READING