[1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),4-valine,-8-D-arginine]vasopressin, a potent and selective inhibitor of the vasopressor response to arginine-vasopressin.

@article{Lowbridge19781betamercaptobetabetacyclopentam,
  title={[1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),4-valine,-8-D-arginine]vasopressin, a potent and selective inhibitor of the vasopressor response to arginine-vasopressin.},
  author={J. Lowbridge and M. Manning and J. Haldar and W. H. Sawyer},
  journal={Journal of medicinal chemistry},
  year={1978},
  volume={21 3},
  pages={
          313-5
        }
}
  • J. Lowbridge, M. Manning, +1 author W. H. Sawyer
  • Published 1978
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • As part of a program in which we are attempting the design and synthesis of an antagonist of the antidiuretic response to arginine-vasopressin (AVP) [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),4-valine,8-D-arginine]vasopressin [d(CH2)5VDAVP] was synthesized and assayed for antidiuretic, vasopressor, and oxytocic activities. The required protected intermediate was synthesized by a combination of solid-phase synthesis and an [8 + 1] coupling in solution. d(CH2)5VDAVP has an… CONTINUE READING
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