[1,2,4]Triazole derivatives as 5-HT(1A) serotonin receptor ligands.

@article{Sarv2002124TriazoleDA,
  title={[1,2,4]Triazole derivatives as 5-HT(1A) serotonin receptor ligands.},
  author={M. Sarv{\`a} and G. Romeo and F. Guerrera and M. Siracusa and L. Salerno and F. Russo and A. Cagnotto and M. Goegan and T. Mennini},
  journal={Bioorganic & medicinal chemistry},
  year={2002},
  volume={10 2},
  pages={
          313-23
        }
}
A series of new 4-amino-3-[3-[4-(2-methoxy or nitro phenyl)-1-piperazinyl] propyl]thio]-5-(substitutedphenyl)[1,2,4]triazoles 11a-t was synthesized in order to obtain compounds with high affinity and selectivity for 5-HT(1A) receptor over the alpha(1)-adrenoceptor. A series of isomeric 4-amino-2-[3-[4-(2-methoxy or nitro phenyl)-1-piperazinyl]propyl]-5-(substitutedphenyl)-2,4-dihydro-3H[1,2,4]triazole-3-thiones 12a-r was also isolated and characterized. New compounds were tested to evaluate… Expand
23 Citations
Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives
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