[(3)H]ketanserin binding increases in monkey cortex following basal forebrain lesions with ibotenic acid.

Abstract

The present study investigated the effects of damage to the basal forebrain cholinergic system upon [(3)H]ketanserin binding in the neocortex and hippocampus of monkeys. [(3)H]Ketanserin specifically binds to serotonin type-2 receptor sites. Lesions were placed in the medial septal area, nucleus basalis, or both regions. Ten months later, [(3)H]ketanserin… (More)

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