<ce:sup loc=post>18</ce:sup>F-FECNT: Validation as PET dopamine transporter ligand in parkinsonism

@article{Masilamoni2010cesupLV,
  title={<ce:sup loc=post>18</ce:sup>F-FECNT: Validation as PET dopamine transporter ligand in parkinsonism},
  author={Gunasingh Masilamoni and John R. Votaw and Louis H. Howell and Rosa M Villalba and Yoland Smith},
  journal={Experimental Neurology},
  year={2010},
  volume={226},
  pages={265-273}
}
The positron emission tomography (PET) tracer 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-[18F]-fluoroethyl)-nortropane ((18)F-FECNT) is a highly specific ligand for dopamine transporter (DAT) that yields higher peak striatum-to-cerebellum ratios and offers more favorable kinetics than most (18)F-radiolabeled DAT ligands currently available. The goal of this study is to validate the use of (18)F-FECNT as a PET radiotracer to assess the degree of striatal dopamine terminals denervation and midbrain… CONTINUE READING
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