<ce:italic>Slc26a4</ce:italic>-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction

  title={<ce:italic>Slc26a4</ce:italic>-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction},
  author={Taku Ito and Xiangming Li and Kiyoto Kurima and Byung Yoon Choi and Andrew J. Griffith},
  journal={Neurobiology of Disease},
SLC26A4 mutations can cause a distinctive hearing loss phenotype with sudden drops and fluctuation in patients. Existing Slc26a4 mutant mouse lines have a profound loss of hearing and vestibular function, with severe inner ear malformations that do not model this human phenotype. In this study, we generated Slc26a4-insufficient mice by manipulation of doxycycline administration to a transgenic mouse line in which all Slc26a4 expression was under the control of doxycycline. Doxycycline was… CONTINUE READING