(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.

@article{Manzoni1990trans1aminocyclopentyl13dicarboxyl,
  title={(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes.},
  author={Oliver J Manzoni and Laurent Fagni and Jean-Philippe Pin and François Rassendren and Francis Poulat and Fritz Sladeczek and J{\"o}el Bockaert},
  journal={Molecular pharmacology},
  year={1990},
  volume={38 1},
  pages={
          1-6
        }
}
The effects of a novel glutamate analogue, (trans)-1-amino-cyclopentyl-1,3-dicarboxylate (ACPD), have been tested in striatal neurons in primary culture and in Xenopus oocytes injected with rat brain RNA. Both systems have been previously shown to contain well characterized metabotropic receptors coupled to phospholipase C (Qp), as well as ionotropic glutamate receptors. In striatal neurons, ACPD stimulated inositol phosphate (InsP) accumulation (EC50 = 9.7 +/- 2.5 microM; maximal effect, 184.7… CONTINUE READING
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