(p)ppGpp synthetases regulate the pathogenesis of zoonotic Streptococcus suis.

@article{Zhu2016pppGppSR,
  title={(p)ppGpp synthetases regulate the pathogenesis of zoonotic Streptococcus suis.},
  author={Jiawen Zhu and Tengfei Zhang and Zhipeng Su and Lu Li and Dong Wang and Ran Xiao and Mabel Teng and Meifang Tan and Rui Zhou},
  journal={Microbiological research},
  year={2016},
  volume={191},
  pages={
          1-11
        }
}
(p)ppGpp-mediated stringent response is one of the main adaption mechanism in bacteria, and the ability to adapt to environment is linked to the pathogenesis of bacterial pathogens. In the zoonotic pathogen Streptococcus suis, there are two (p)ppGpp synthetases, RelA and RelQ. To investigate the regulatory functions of (p)ppGpp/(p)ppGpp synthetases on the pathogenesis of S. suis, the phenotypes of the [(p)ppGpp(0)] mutant ΔrelAΔrelQ and its parental strain were compared. Light and electron… CONTINUE READING
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