(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

@article{Pratilas2009V600EBRAFIA,
  title={(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.},
  author={Christine A. Pratilas and Barry S. Taylor and Qing Ye and Agnes J. Viale and Chris Sander and David B. Solit and Neal Rosen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 11},
  pages={
          4519-24
        }
}
Tumors with mutant BRAF and those with receptor tyrosine kinase (RTK) activation have similar levels of phosphorylated ERK, but only the former depend on ERK signaling for proliferation. The mitogen-activated protein kinase, extracellular signal-regulated kinase kinase (MEK)/ERK-dependent transcriptional output was defined as the genes whose expression changes significantly 8 h after MEK inhibition. In (V600E)BRAF cells, this output is comprised of 52 genes, including transcription factors that… CONTINUE READING

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