(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

@inproceedings{Dai2017ScrizotinibIA,
  title={(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1},
  author={Xuanxuan Dai and Gui-long Guo and Peng Zou and Ri Cui and Weiqian Chen and Xi Chen and Changtian Yin and Wei He and Rajamanickam Vinothkumar and Fan Yang and Xiaohua Zhang and Guang Liang},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2017}
}
BACKGROUND Non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes in patients with NSCLC as a number of oncogenic drivers have been found. Crizotinib, a selective small-molecule inhibitor, has been widely… CONTINUE READING