(S)-ZJM-289 Preconditioning Induces a Late Phase Protection Against Nervous Injury Induced by Transient Cerebral Ischemia and Oxygen-Glucose Deprivation

@article{Zhang2013SZJM289PI,
  title={(S)-ZJM-289 Preconditioning Induces a Late Phase Protection Against Nervous Injury Induced by Transient Cerebral Ischemia and Oxygen-Glucose Deprivation},
  author={Chao Zhang and Zhenzhen Zhang and Qian Zhao and Xuliang Wang and Hui Jiao Ji and Yihua Zhang},
  journal={Neurotoxicity Research},
  year={2013},
  volume={26},
  pages={16-31}
}
(S)-ZJM-289, a novel nitric oxide (NO)-releasing derivative of 3-n-butylphthalide, induces the neuroprotection in a rat model of focal cerebral ischemia/reperfusion (I/R). However, much is unknown about the late phase effect in the neuroprotection of (S)-ZJM-289 preconditioning. The purpose of this study is to explore the late phase neuroprotection of (S)-ZJM-289 preconditioning, as well as underlying mechanisms involved. Preconditioning with 40–160 mg/kg, (S)-ZJM-289 significantly reduces… CONTINUE READING
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