(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.

@article{Bell2007SN31cyclopropyl124difluorophenylethyl,
  title={(S)-N-\{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl\}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.},
  author={Michael G Bell and Douglas L Gernert and Timothy A Grese and Matthew D Belvo and Peter S Borromeo and Sally Ann Kelley and Joseph H Kennedy and Stanley P. Kolis and Peter A Lander and Rachel N Richey and V. Scott Sharp and Gregory A. Stephenson and Jeffrey D Williams and Hannah Yu and Karen Zimmerman and Mitchell I. Steinberg and Prabhakar K. Jadhav},
  journal={Journal of medicinal chemistry},
  year={2007},
  volume={50 26},
  pages={6443-5}
}
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lowering at pharmaceutically relevant doses. 

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