(S)-Albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle.

@article{Mitra1998SAlbuterolII,
  title={(S)-Albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle.},
  author={Sudipan Mitra and Mehmet Uğur and Ozlem Uğur and H. M. Goodman and JOHN R. MCCULLOUGH and Hitoshi Yamaguchi},
  journal={Molecular pharmacology},
  year={1998},
  volume={53 3},
  pages={347-54}
}
Racemic albuterol has been one of the most widely used beta2-adrenoceptor agonists for the relief of the symptoms of asthma, yet the use of beta2 agonists has been known to induce bronchial hyperresponsiveness. To probe a possible role of the S-enantiomer for hyperresponsiveness, we determined the effects of (S)-albuterol on intracellular Ca2+ concentration ([Ca2+]i) in dissociated bovine tracheal smooth muscle cells. Both (S)-and (R,S)-albuterol increased [Ca2+]i at concentrations of >10 pM… CONTINUE READING

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