(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.

@article{Decker1994S3methyl51methyl2pyrrolidinylisoxaz,
  title={(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.},
  author={Michael W. Decker and Jorge D. Brioni and James P. Sullivan and Michael J. Buckley and Richard J. Radek and Joanna L. Raszkiewicz and Chae Hee Kang and Dai Jin Kim and William J Giardina and J T Wasicak},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={270 1},
  pages={319-28}
}
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418), an isoxazole analog of (-)-nicotine, is a potent agonist at the alpha-4/beta-2 subtype of neuronal nicotinic acetylcholine receptor (nAChR) that exists in mammalian brain (Arneric et al., 1994). Compared to (-)-nicotine, ABT 418 has reduced potency to interact with the subunit isoforms of nAChR found in sympathetic ganglia, and it does not compete for alpha-bungarotoxin binding sites in brain or at the neuromuscular junction. ABT 418… CONTINUE READING

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