(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy.

@article{Gordon2010RA,
  title={(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy.},
  author={Andrea L Gordon and Olga V Lopatko and Andrew Alexander Somogyi and D. J. Foster and J. Maunsell White},
  journal={British journal of clinical pharmacology},
  year={2010},
  volume={70 6},
  pages={895-902}
}
AIMS The aim of this study was to compare the transfer of buprenorphine and methadone between maternal and cord blood in women under chronic dosing conditions and to determine if differences exist in the transfer of the two methadone enantiomers. METHODS Maternal and cord blood samples were collected at delivery from women maintained on methadone (35, 25-140 mg day⁻¹) (median; range) or buprenorphine (6.00, 2-20 mg day⁻¹) during pregnancy. Plasma concentration ratios are presented as an… CONTINUE READING

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