(R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats.

@article{Li2014RalphamethylhistamineSI,
  title={(R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats.},
  author={Weiwei Li and Long-Zhen Cheng and Zui Zou and Mou-Li Tian and Hao Zhang and Abou Dargham Raya and Yun Wang and Xueyin Shi},
  journal={CNS neuroscience & therapeutics},
  year={2014},
  volume={20 9},
  pages={851-9}
}
BACKGROUND Propofol is a short-acting, intravenous general anesthetic that is widely used in clinical practice for short procedures; however, it causes depressed cognitive function for several hours thereafter. (R)-alpha-methylhistamine (RAMH), a selective histamine H3 receptor agonist, can enhance memory retention and attenuates memory impairment in rats. In this study, we investigated whether RAMH could rescue propofol-induced memory deficits and the underlying mechanisms partaking in this… CONTINUE READING
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