(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

@inproceedings{Syvnen2011R11CVerapamilPS,
  title={(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus},
  author={Stina Syv{\"a}nen and Gert Luurtsema and Carla F. M. Molthoff and Albert D. Windhorst and Marc C. Huisman and Adriaan A. Lammertsma and Rob A. Voskuyl and Elizabeth C. de Lange},
  booktitle={BMC Medical Imaging},
  year={2011}
}
BACKGROUND Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and… CONTINUE READING
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