(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma

  title={(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma},
  author={Yuki Shibayama and Takayuki Fujimori and Genevi{\`e}ve Nguyen and Takuo Hirose and Kazuhito Totsune and Atsuhiro Ichihara and Kento Kitada and Daisuke Nakano and Hiroyuki Kobori and Masakazu Kohno and Tsutomu Masaki and Yasuyuki Suzuki and Shinichi Yachida and Akira Nishiyama},
  booktitle={Scientific reports},
Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin activation. Recent studies have implicated the (pro)renin receptor ((P)RR) is related to the Wnt/β-catenin signaling pathway. We therefore investigated the possible role of (P)RR in pancreatic carcinogenesis. Plasma s(P)RR levels were significantly (P < 0.0001) higher in patients with… CONTINUE READING


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