(99m)Tc-MAG3-aptamer for imaging human tumors associated with high level of matrix metalloprotease-9.

Abstract

The human matrix metalloprotease 9 (hMMP-9) is involved in many physiological processes such as tissue remodeling. Its overexpression in tumors promotes the release of cancer cells thus contributing to tumor metastasis. It is a relevant marker of malignant tumors. We selected an RNA aptamer containing 2'-fluoro, pyrimidine ribonucleosides, that exhibits a… (More)
DOI: 10.1021/bc300146c

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