(2S)-2′-methoxykurarinone from Sophora flavescens suppresses cutaneous T cell-attracting chemokine/CCL27 expression induced by interleukin-ß/tumor necrosis factor-α via heme oxygenase-1 in human keratinocytes.

@article{Jeong20102S2methoxykurarinoneFS,
  title={(2S)-2′-methoxykurarinone from Sophora flavescens suppresses cutaneous T cell-attracting chemokine/CCL27 expression induced by interleukin-\ss/tumor necrosis factor-α via heme oxygenase-1 in human keratinocytes.},
  author={Seung-il Jeong and Young-eun Lee and Seon Il Jang},
  journal={Journal of medicinal food},
  year={2010},
  volume={13 5},
  pages={1116-24}
}
One of the CC chemokines, cutaneous T cell-attracting chemokine (CTACK/CCL27), is a skin-specific CC chemokine that is produced constitutively by keratinocytes and is highly up-regulated in inflammatory skin conditions such as atopic dermatitis and contact dermatitis. (2S)-2′-Methoxykurarinone (MOK) from Sophora flavescens has been demonstrated to have antioxidant effects. Heme oxygenase (HO)-1 has recently emerged as an important cytoprotective enzyme against oxidative stress and inflammatory… CONTINUE READING

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