(19)F-encoded combinatorial libraries: discovery of selective metal binding and catalytic peptoids.

@article{Pirrung200219FencodedCL,
  title={(19)F-encoded combinatorial libraries: discovery of selective metal binding and catalytic peptoids.},
  author={Michael C. Pirrung and Kaapjoo Park and L Nathan Tumey},
  journal={Journal of combinatorial chemistry},
  year={2002},
  volume={4 4},
  pages={
          329-44
        }
}
A (19)F NMR method for encoding of combinatorial libraries has been developed. Aryl fluorides whose chemical shifts are modified by aromatic substituents were prepared and attached to resin support beads that were used in the split-pool synthesis of peptoids. The detection of the (19)F NMR signal of tags derived from a single "big bead" was demonstrated. The library diversity arises from peptoid amines and the cyclic anhydrides used in their acylation. The resulting 90-compound library was… CONTINUE READING
BETA